Gynecological cancers encompass a group of malignancies affecting a woman’s reproductive organs, including cervical, ovarian, uterine, vaginal, and vulvar cancers. Each type has unique symptoms, risk factors, and treatment options, but early detection is key to improving outcomes across all forms. Common risk factors include age, family history, genetic mutations like BRCA1/BRCA2, and lifestyle factors such as smoking and obesity. Advances in screening, such as Pap smears for cervical cancer, along with diagnostic tools like ultrasound and genetic testing, have greatly aided in early diagnosis. Treatment approaches, which may include surgery, chemotherapy, and radiation therapy, are tailored to the specific type and stage of the cancer.
Endometrial cancer, or uterine cancer, arises from the endometrium, the lining of the uterus. It is the most common type of uterine cancer and typically occurs in postmenopausal women. Early detection often leads to a good prognosis, making awareness of symptoms crucial.
While the exact cause remains unclear, certain risk factors increase the likelihood of developing endometrial cancer, including obesity, hormone replacement therapy, early menstruation or late menopause, and certain genetic conditions like Lynch syndrome.
Diagnosis often begins with a review of medical history and physical examination, followed by diagnostic tests such as:
Uses sound waves to create images of the uterus
A sample of the uterine lining is taken for laboratory analysis
A thin tube with a camera is inserted into the uterus to examine the lining
Imaging tests like CT scans or MRIs may also be utilized to determine the cancer's stage and extent.
Treatment options for endometrial cancer depend on the stage and grade of the cancer and may include:
Hysterectomy: Removal of the uterus and sometimes the ovaries and fallopian tubes (bilateral salpingo-oophorectomy).
Lymph Node Removal: Nearby lymph nodes may also be removed to check for cancer spread.
Surgery is the primary treatment in most cases, especially for early-stage cancer.
External Beam Radiation Therapy (EBRT): High-energy beams target cancer cells from outside the body.
Brachytherapy: A radioactive source is placed inside the vagina to target the cancer site more directly.
Radiation is often used to prevent recurrence after surgery or as a primary treatment for those unable to undergo surgery.
Used for advanced or recurrent cases, hormone therapy involves progesterone or anti-estrogen drugs like megestrol acetate.
This therapy helps slow the cancer’s growth, especially in cancers that depend on hormones like estrogen.
Common drugs include carboplatin and paclitaxel. Chemotherapy is recommended for advanced-stage or high-grade cancers.
It may be given alone or combined with radiation or other treatments for better outcomes.
Drugs like lenvatinib (used with pembrolizumab) target specific molecular pathways involved in cancer growth.
Targeted therapy is mainly used for advanced cases or when cancer has spread.
Immune Checkpoint Inhibitors: Immune Checkpoint Inhibitors like pembrolizumab help the immune system fight cancer by blocking proteins that prevent immune attacks.
Immunotherapy is recommended for cases resistant to other treatments or for cancers with specific genetic markers (like MSI-H or dMMR).
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